... es un ensayo clínico: Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands, evaluando el tratamiento intraarterial de las oclusiones agudas proximales de la circulación anterior (los resultados sugieren que mejora los resultados funcionales). Se publicó en el New England el 1 de enero
http://www.nejm.org/doi/pdf/10.1056/NEJMoa1411587
En el mismo enlace hay un vídeo resumen con animación que dura 2:30 minutos
El editorial también habla del mismo tema, el editorialista "se moja" a aventurar el por qué del éxito de los investigadores http://www.nejm.org/doi/pdf/10.1056/NEJMe1413346
* Es un ensayo pragmático, para el que no esté familiarizado con el término:
Patsopoulos 2012: "The term explanatory was used to describe trials that aim to evaluate the efficacy of an intervention in a well-defined and controlled setting, whereas the term pragmatic was used for trials designed to test the effectiveness of the intervention in a broad routine clinical practice. The explanatory trial is the best design to explore if and how an intervention works, and the whole experiment is designed in order to control for all known biases and confounders, so that the intervention's effect is maximized. Usually the intervention under examination is compared with a placebo or with another active treatment. The pragmatic trial, on the other hand, is designed to test interventions in the full spectrum of everyday clinical settings in order to maximize applicability and generalizability. The research question under investigation is whether an intervention actually works in real life. The intervention is evaluated against other ones (established or not) of the same or different class, in routine practice settings. Pragmatic trials measure a wide spectrum of outcomes, mostly patient-centered, whereas explanatory trials focus on measurable symptoms or markers (clinical or biological). "
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